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1. AV on all client machines and servers
2. No VPN connections from non-company control machines (users should not be able to VPN from their home malware infested PC's)
3. You should deploy AppLocker organization wide, which only allows whitelisted .exe's to be executed. This single security measure make's it almost unnecessary to run AV (but you should still run it).
4. No user should be local admins of their PC
5. You should have very many domain admin accounts
6. Install dual factor auth on all your servers (and PC's ideally), such as Duo authentication
Very good list, though with vulnerabilities in Excel/Word/Acrobat/etc., I think #3 is overstated.
#5 doesn't get emphasized enough elsewhere. Our company is fairly tight on security, but if you're give an alternate admin account it's good for all the systems you might need to reach. That's just not wise, IMHO. They at least do make it a violation of Corporate Standards to surf the web, etc. while in your admin account.
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