http_post consumer API calls in a mass volume situation

Let me start with just a pretty generic question and scenario.

If you had a need to send a large volume of http API consumer requests
from your native applications (and db2)... is it correct to think that
http_post may not exactly be the best choice as it is real time
synchronous...
If so, what are some other good options?

Or am I wrong? Could you expect http_post to hold up.

Pretty speculative scenario I realize - but imagine a level of volume that
you may consider moderate to high even for your native applications to go
after db2 data locally - but instead, those "i/o"s are considering to be
replaced with http_post to another system.
As a change occurs in the application, that change is pushed over off
platform via http via the http_post...

can it work?
what are the considerations?
Also this would be with https (ssl authentication in play)

tia

jay