Time lag for interactive processes over transatlantic link -- MIDRANGE-L

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hi,
I'm interested in companies that have a centralised server(s) on one size of
the atlantic, but who have users accessing it from the other (via leased
line and/or web based).  
My company is considering a US based server farm, that handles the global
business.
Given the inherant lags over a transatlantic link, what sort of interactive
response time do users experience?  It it viable do do this without a
replica server at either end?
Is the performance of local users affected by the remote ones?

Thanks
Stuart


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